Autoimmune Disease Research
Our autoimmune disease research program is dedicated to uncovering the root causes of chronic conditions where the immune system mistakenly attacks the body’s own tissues. These diseases affect approximately 8% of the U.S. population (NIH).
Finding the causes of and cures for a variety of autoimmune diseases.
Our scientists are focused on identifying novel genes and pathways involved in the development of autoimmune disorders such as systemic lupus erythematosus (SLE), Type 1 diabetes and rheumatoid arthritis. By studying the molecular targets impacting these genetic alterations, we aim to advance diagnostic techniques and develop innovative therapies that target and treat more effectively. Ultimately, our goal is to improve treatment options and pave the way for potential cures for these debilitating conditions.
Lupus, or systemic lupus erythematosus (SLE), is a complex autoimmune disease in which the immune system mistakenly targets healthy tissues, causing widespread inflammation and damage to organs and systems throughout the body. Though the exact cause remains unclear, it is believed to result from a combination of genetic, environmental, and hormonal factors. Our research focuses on unraveling these causes to develop more effective treatments and potentially a cure for this debilitating condition.
Type 1 diabetes is a lifelong autoimmune condition in which the immune system destroys insulin-producing beta cells in the pancreas, leading to a lack of insulin and an inability to regulate blood sugar levels. Our research aims to uncover the underlying genetic and immunological factors that trigger this autoimmune response, with the goal of developing treatments that can prevent or reverse the destruction of beta cells, and ultimately lead to better management or even a cure.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder primarily affecting the joints, where the immune system attacks the synovium, the lining of the joints. This leads to persistent inflammation, pain, and eventual joint damage. Unlike osteoarthritis, which is caused by wear and tear, RA is driven by an immune response. Our research is centered on understanding the mechanisms behind this immune attack, aiming to discover targeted therapies that can slow or halt the progression of this disease.
Research Labs Working onAutoimmune Disease
Kessinger Lab
Is investigating how immune cell activity in SLE can lead to the development of venous thromboembolism.
Kontaridis Lab
Is studying how the increased activity of specific biological enzymes in the body can affect the progression and pathogenesis of SLE, including the development of lupus nephritis and lupus-associated myocarditis.
McCarthy Lab
Is developing novel therapeutic agents for the treatment of SLE and lupus nephritis.
News About OurAutoimmune Disease Research
MMRI and LADA Host 2026 Lupus Walk in Utica
Masonic Medical Research Institute (MMRI), in partnership with Lupus and Allied Diseases Association, Inc. (LADA), hosted its third annual Lupus…
DOD Awards Research Grant to MMRI Scientist Investigating Techniques to Monitor Transplant Health in Wounded Veterans
Jason R. McCarthy, Ph.D., hopes to improve the quality of life for millions of soldiers following traumatic events UTICA, N.Y.…
MMRI and LADA Hold Walk to Support Lupus Research in Honor of Lupus Awareness Month
On Saturday, May 17, 2025, the Masonic Medical Research Institute (MMRI) hosted more than 250 people at the Masonic Care…
MMRI awarded $200,000 by Lupus and Allied Diseases Association
On Thursday, August 14, 2024, officials from MMRI received a surprise announcement by LADA President and CEO, Kathleen Arntsen, that…
MMRI Holds Utica’s First Walk to Support Lupus Research in Honor of Lupus Awareness Month
On Saturday, May 18, 2024, MMRI hosted more than 350 people at the Masonic Care Community Campus, located at 2150…
$200,000 Awarded to MMRI for Research on Lupus by The Lupus and Allied Diseases Association, Inc. (LADA)
$200,000 Awarded to MMRI for Research on Lupus by The Lupus and Allied Diseases Association, Inc. (LADA) Funding to support…
Samantha Le Sommer: The Rising Tide Raises All Ships
Our very own Samantha Le Sommer, Ph.D., under Maria Kontaridis, Ph.D., executive director, was published in Wiley. Her article “The…
Research Takes Center Stage at Lupus Awareness Event
May 19, 2023 The Lupus and Allied Diseases Association, Inc., and MMRI teamed up on May 19 at the MMRI…